How Coenzyme Q10 + Vitamin E Impacts Retinal-Evoked and Cortical-Evoked Responses in Patients With OAG
In the following study, researchers evaluated pattern-evoked retinal and cortical responses [pattern electroretinogram (PERG) and visual-evoked potential, respectively] following treatment with coenzyme Q10 in conjunction with vitamin E in open-angle glaucoma patients. They found that coenzyme Q10 associated with vitamin E administration in OAG shows a beneficial effect on the inner retinal function (PERG improvement) with consequent enhancement of the visual cortical responses (VEP improvement).
To reach this conclusion, they enrolled 43 OAG patients (mean age, 52.5 ± 5.29 y; intraocular pressure <18 mmHg with beta-blocker monotherapy only). At baseline and after six and 12 months, the researchers obtained simultaneous recordings of PERG and VEPs from 22 OAG patients who underwent treatment consisting of coenzyme Q10 and vitamin E (Coqun, b.i.d.) in addition to beta-blocker monotherapy (GC Group), as well as from 21 OAG patients who were only treated with beta-blockers (GP Group).
They discovered that at baseline, IOP, PERG and VEP parameters were similar in both GC and GP groups (analysis of variance, p>0.05). They also noted that after six and 12 months, PERG and VEP response parameters of GP patients were unchanged when compared to baseline. In GC patients, PERG P50 and VEP P100 implicit times were decreased, whereas PERG P50-N95 and VEP N75-P100 amplitudes were increased (p<0.01) when compared to baseline. In the GC Group, the differences in implicit times and amplitudes with respect to baseline were significantly larger (p<0.01) than those recorded in the GP Group. The improvement (12 months minus baseline) of VEP implicit time was significantly correlated with the changes of PERG P50-N95 amplitude (r=–0.66171, p=0.0008) and P50 implicit time (r=0.68364, p=0.00045) over a period of 12 months.