Mortality of Patients with CRVO
Researchers in Denmark assessed mortality in patients with central retinal vein occlusion (CRVO) in the following registry-based cohort study.
Included were 439 photographically verified CRVO patients and a control cohort of 2,195 unexposed subjects matched by age and gender and alive on the date CRVO was diagnosed in the corresponding case. The researchers used data from nationwide registries to compare mortality rates in CRVO patients with a control cohort over a mean follow-up of 5.1 years for cases and of 5.7 years for controls. Hazard ratios (HRs) obtained by Cox regression and standardized mortality ratios (SMRs) stratified by age and gender served as measures of relative mortality risk.
According to the researchers, mortality was higher in patients with CRVO (HR, 1.45; 95% confidence interval [CI], 1.19 to 1.76) than in the control cohort, adjusted for age, gender and time of diagnosis. They noted that mortality was comparable between the two groups (HR, 1.19; 95% CI, 0.96 to 1.46) when adjusting for overall occurrence of cardiovascular disease and diabetes. Additionally, subgroup analysis found that the age-stratified mortality rate was increased significantly in the total group of men (SMR, 1.27; 95% CI, 1.03 to 1.56) and in women 60 to 69 years of age (SMR, 1.94; 95% CI, 1.22 to 3.08).
In conclusion, CRVO was associated with an overall increase in mortality compared with controls that was attributed statistically to cardiovascular disorders and diabetes. The researchers recommend treatment of hypertension and diabetes, if present, and referral of patients found to have CRVO who are not already being treated by a primary care physician.