Fluctuation in IOP in Patients Who Have POAG Plus High Myopia
Here, the authors of a prospective control clinical study investigate whether patients with primary open-angle glaucoma (POAG) combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise.
They categorized 80 eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally as per their degree of myopia (myopes ≥6D, n=30 and between –0.76D and –5.99D, n=29) or without myopia (n=21). They observed 24-hour IOP fluctuations at resting conditions in protocol one, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) followed by five minutes of exercise at 60% Wmax in protocol two.
The study authors noted that 24-hour IOP fluctuations at resting conditions were not statistically significant among groups (p=0.58). They also found that, after 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50 ± 2.76 mmHg) over other subjects (analysis of covariance, age, as a covariate, was controlled, p=0.02). After five minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57 ± 3.47 mmHg) than other groups (p=0.00).
In conclusion, high-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.